Availability: In Stock (28 packs)
Manufacturer: Sun Pharmaceutical Industries Ltd. / Svizera Labs Private Limited
Disease(s): Infections of stomach and intestines / Middle ear / Sinuses / Bladder / Kidney
Ampicillin is an antibiotic from aminopenicillin group designed to fight with infections of stomach and intestines, middle ear, sinuses, bladder, and kidney.
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What is Ampicillin?
Ampicillin, a drug popular for many years, is an effective antibiotic. Despite the fact that new drugs have appeared, it is still in demand by doctors and patients. This semi-synthetic penicillin antibiotic is effective against many bacteria, and it helps better than others from sepsis and purulent infection. Not everyone knows exactly why Ampicillin helps, although its low price and availability in pharmacies make it one of the most purchased drugs. Many patients prescribe it for themselves, which, of course, should not be done. The use of Ampicillin should be strictly prescribed by the doctor, which takes into account the patient’s health status and features of his disease. You need to know exactly why Ampicillin helps, so as not to cause the development of superinfection, insensitive to antibiotics.
Pharmacological action of ampicillin
Ampicillin is active against gram-positive and some gram-negative microorganisms, as well as non-spore-forming bacteria, but is ineffective against penicillin-producing strains, as it is destroyed by penicillinase.
After ingestion, good absorption from the gastrointestinal tract is noted, the drug is not fed to the destruction in the acidic environment of the stomach, showing acid resistance. With parenteral administration, the amount of Ampicillin in blood plasma exceeds its content, which is formed when taken orally. The drug penetrates into most tissues and organs; its presence in therapeutic concentrations is noted in pleural, amniotic, synovial fluids, in bronchial secretions, saliva, and fetal tissues. For the most part, it is excreted in the urine and partially in the bile, it does not accumulate, which makes it possible to use it for a long time in high doses.
Indications for the use of Ampicillin
- Abscess of the lung;
- Urinary tract infections;
- Intestinal infections;
- Gynecological infections.
Methods of use and dosage
Before starting a course of treatment in the absence of a patient’s history of allergic reactions, skin tests for antibiotic tolerance should be performed. According to the instructions for use, Ampicillin is prescribed orally, intramuscularly and intravenously, in a stream and drip.
The daily dose for adults and children weighing more than 20 kg is 1-3 g, a single dose is 250-500 mg 4 times a day, with severe infection 1000-2000 mg every 3-4 hours.
For children weighing less than 20 kg — 12.5-25 mg / kg every 6 hours or 16.7 — 33.3 mg / kg every 8 hours. Ampicillin tablets are taken orally 0.5-1 hours before a meal, with the course of the disease in children in a mild form, it is preferable to prescribe the drug in the form of a suspension.
The duration of treatment with Ampicillin tablets or its other forms is set individually depending on the severity of the disease and the sensitivity of the pathogen.
The course can last from 5-10 days to 2-3 weeks or more. After the disappearance of clinical signs, it is necessary to continue treatment for another 2-3 days, with a course of treatment more than 7 days, it is necessary to monitor liver and kidney function (at least once a week).
- the drug is used with caution in bronchial asthma, hay fever, with the use of desensitizing agents;
- in the process of treatment, periodic monitoring of the function of the kidneys, liver, and blood is required;
- in case of impaired kidney or liver, a dose adjustment is performed;
- high doses of the drug can lead to toxic effects;
- during sepsis therapy, a bacteriolysis reaction may develop;
- if allergic reactions appear, treatment is canceled; debilitated patients may develop superinfection, which requires discontinuation of drug therapy;
- for the prevention of candidiasis during treatment with Ampicillin, it is advisable to take Nystatin, Levorin, ascorbic acid and B vitamins.
Doctors are allowed to take the antibiotic Ampicillin during pregnancy, but only when the potential benefit to the mother exceeds the possible risk for the development and growth of the fetus. When taking the drug when carrying a child, special careful monitoring of the picture of peripheral blood and the functioning of all systems of the unborn baby is required.
Ampicillin for lactation
During lactation, the active substance of the composition passes into breast milk and is found there in low concentrations. If a nursing mother is taking the medication, then stopping breastfeeding should be considered. If this is not possible, a woman is transferred to treatment with safer means to eliminate pathogenic microflora in the body.
Ampicillin for children
According to the instructions, Ampicillin can be prescribed to children from the first month of life in the form of parenteral administration of a solution. From a year you can prescribe a suspension obtained from the powder. The dosage of the drug differs depending on body weight and is 50-100 mg / kg, with a weight of less than 20 kg — 12.5-25 mg / kg. The daily dose of injections for newborns is 100 mg / kg, for children older than a month — 50 mg / kg.
Ampicillin and alcohol
Doctors are strictly forbidden to take alcohol and alcohol-containing drinks or drugs during medication treatment. This leads to an increase in the load on the liver, a decrease in its working capacity and an increase in the risk of an overdose. If there are even slight congenital changes in the liver, then hepatitis, jaundice and even death can occur.
Ampicillin is contraindicated in case of hypersensitivity to penicillin, cephalosporin, carbapenem, as well as with lymphocytic leukemia, infectious mononucleosis.
With liver failure, the drug is used with constant monitoring of its concentration in blood plasma. In case of emergency, it is used for bronchial asthma, hay fever and other allergic diseases.
With caution, Ampicillin should be taken with renal failure, pregnancy, children under the age of 1 month.
- Allergic manifestations in the form of: itching, rhinitis, conjunctivitis, urticaria, exfoliative dermatitis, erythema multiforme exudative. Very rarely in the form of Quincke’s edema and anaphylactic shock;
- Gastrointestinal reactions: dry mouth, nausea, vomiting, pain in the abdomen, diarrhea, intestinal dysbiosis, gastritis, stomatitis, taste change;
- From the central nervous system: headache, neuropathy, tremor, convulsions (when used in high doses).
If the dose of the medicine is exceeded for a long time, an overdose may occur. Its symptoms include dizziness, headache, loose stools, and vomiting. Sometimes skin allergic rashes appear. If these symptoms occur, you must cancel the drug and consult a doctor for treatment. It is advisable to induce vomiting and drink activated charcoal or another sorbent.