Availability: In Stock (34 packs)
Active Ingredient: Clindamycin Hydrochloride
Manufacturer: Alembic Pharmaceuticals Ltd. / Ranbaxy Laboratories Ltd.
Clindamycin is an antibiotic that fights bacteria in the body.Clindamycin is used to treat serious infections caused by bacteria.
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What is Clindamycin?
Clindamycin is a narrow-spectrum antibiotic that can cope with severe infectious diseases.
In the treatment of infectious diseases, the use of narrowly targeted antibiotics is justified, since over time, the resistance of pathogenic microorganisms to broad-spectrum antiviral drugs is developed. Clindamycin is a semi-synthetic antibiotic of the linkosamine series, used to treat infections caused by anaerobic bacteria. This drug is a derivative of lincomycin, but has more advanced pharmacological characteristics.
Composition and form of release
Clindamycin is available in various forms, which contributes to its wide therapeutic use. The drug is packaged in cardboard boxes with:
- Capsules of 8 pieces in a blister. The package contains 2 blisters.
- Solution for intramuscular and intravenous administration. Ampoules are packaged in 5 pieces in two cell coasters.
- Granules for the preparation of syrup — in a glass bottle.
- Vaginal cream — in an aluminum tube with 7 single applicators.
- Vaginal suppositories — 3 suppositories.
- Gel for external use — in an aluminum tube.
This antibiotic is developed on the basis of Linkomycin — one of its hydroxyl groups is replaced by chlorine.
The antibiotic Clindamycin is active against pneumocysts, toxoplasmas, anaerobic bacteria, except strains resistant to antibiotics of the group of linkisides. It is characterized by a high degree of penetration of the drug substance to the place affected by the infection, regardless of the time the patient takes the drug. Indispensable in cases of intolerance to patients with penicillins. It can be used in combination with other drugs that fight gram-negative bacteria.
This antibiotic is widely used to treat infections of soft and bone tissues, joints, and respiratory tract affected by the following pathogenic bacteria: Staphylococcus, Pneumococcus, Corynebacterium, Mycoplasma, Chlamydia trachomatis, Clostridia, Bacteroids frigalis, Bacteroids melanenicus.
Pharmacodynamics and pharmacokinetics
Clindamycin penetrates well into all fluid media, soft tissues of the body and bones. The drug inhibits the synthesis of proteins in the cells of pathogenic microorganisms, exhibiting a bacteriostatic and bactericidal effect. There are a number of bacteria resistant to this antibiotic: Gonococcus Neisser, Candida albicans, Vaginal Trichomonas, Enterococcus, Clostridia, Herpes simplex.
The maximum concentration of a therapeutic substance in the blood with oral administration is observed faster than with intramuscular administration. The active substance enters the blood 1-3 hours after taking (administering) the drug. Having reached the infected area, it is retained in the body for about 12 hours, while almost 90% of the substance binds to the proteins of pathogenic microorganisms. Clinical studies have not revealed the accumulation of the active substances of the drug. It is processed by the liver. Metabolites are excreted completely after 4 days with urine, bile and feces.
Indications for use
Clindamycin is used to treat infectious diseases caused by pathogenic microorganisms that are sensitive to the active substance of the drug:
- abdominal cavity and intestines (abscess, peritonitis);
- the oral cavity (periodontal abscess);
- urogenital area (bacterial vaginosis, chlamydia, vaginal dysbiosis, vaginal candidiasis, endometritis);
- infections of the throat, ear, nose, upper and lower respiratory tract (otitis media, tonsillitis, pharyngitis, sinusitis, empyema of the pleura, diphtheria, scarlet fever, pneumonia, etc.);
- skin and soft tissues (felon, furuncle, impetiglo, erysipelas, infected wounds);
- infections of the joints and bones (septic arthritis, osteomyelitis);
- tropical malaria;
- infectious inflammation of the inner lining of the heart (endocarditis);
- anaerobic septicemia (blood poisoning).
Method of use and dosage
Antibiotic treatment is strictly under the supervision of a doctor. The choice of the form of the drug, its dosage and time of administration, depend on:
- patient age;
- his well-being;
- areas of infection of the body;
- severity of the course of the disease;
- the sensitivity of the pathogen to the active substance of the drug.
Clindamycin tablets are used after achieving a clinical effect, every 6 hours, 450 mg each until the completion of a two-week course of therapy.
Clindamycin tablets are also used to treat mild to moderate infectious and inflammatory diseases. Adults are prescribed every 6 hours for 150-450 mg for a period of at least 10 days.
For the treatment of cervical infections that cause chlamydia, Clindamycin tablets are used 4 times a day, 450 mg for 10-14 days.
Antibacterial drugs disrupt the normal intestinal flora. Pseudomembranous colitis can develop during the use of this antibiotic and 3 weeks after the course. It is necessary to treat diarrhea and other dangerous symptoms in the indicated period as a manifestation of this diagnosis. In elderly people, with the use of antibiotics, pseudomembranous colitis appears more often and is more severe. For the treatment of colitis, ion-exchange resins, Vancomycin or Metronidazole are prescribed.
The use of this antibiotic can lead to a significant increase in pathogenic bacteria that are insensitive to it. Depending on the type of infection that has grown, it is necessary to carry out the necessary therapy. When using high doses of this antibiotic, it is very important to control the level of the active substance in the blood plasma. Before prescribing vaginal suppositories or cream to patients, it is necessary to conduct a laboratory analysis for the presence of microorganisms resistant to clindamycin, which cause vulvovaginitis.
During treatment with this antibiotic, women should avoid sexual contact (the active component of the drug reduces the strength of contraceptive products made of latex and rubber). Do not use intravaginal tampons during menstruation during treatment. The antibiotic is not compatible with alcohol. Do not use the drug in the form of a gel after using scrubs to avoid excessive skin irritation.
Clindamycin during pregnancy
Through the placenta, the antibiotic easily penetrates the fetus, therefore, it is not administered orally and parenterally to pregnant women. The effect of the drug in the form of an ointment on the increase in congenital abnormalities of the fetus during intravaginal use by pregnant women in the 2nd and 3rd trimester has not been recorded. This drug should be used in exceptional cases as prescribed by the attending physician and under his constant supervision.
Children under 8 years of age are given an oral antibiotic in the form of a syrup. Granular preparation is intended for self-preparation of syrup (suspension). The vial with granules must be filled with 60 ml of water and shaken well. Calculation of the dose of the drug is based on body weight and age of the child. The daily dose of syrup for children older than 1 month is 8-25 mg per kilogram of weight, divided into 4 doses. The minimum dose for children weighing less than 10 kg is 37 mg (1/2 teaspoon) every 8 hours.
Clindamycin should not be prescribed to nursing mothers. It is forbidden to use the drug with:
- renal and liver failure;
- ulcerative colitis;
- bronchial asthma;
- lactase deficiency;
- asthenic bulbar palsy;
- individual intolerance to the components of the drug;
When using Clindamycin gel for external use, an allergic reaction may occur. To avoid this, before using the medicine, it is necessary to test for individual tolerance of the components of the drug. You need to gel the inner bend of the elbow. If after 2 hours of redness and itching is not — you can use the gel for treatment. When using an antibiotic in the form of a vaginal cream, the manifestation of undesirable effects is possible:
- Urogenital region: irritation of the mucous membrane of the vagina and vulva, pruritus, candidiasis, vulvovaginitis, Trichomonas vaginitis, menstrual cycle, uterine bleeding, endometriosis, dysuria.
- General condition: abdominal pain, flatulence, nausea, vomiting, diarrhea, upper respiratory tract infection, bad breath, dizziness.
- Skin: urticaria, itching.
Taking this antibiotic is accompanied by side effects when used orally and parenterally. Undesirable effects can occur in such body systems:
- Digestion: dysbiosis, pseudomembranous enterocolitis, jaundice, esophagitis.
- Hemopoiesis: neutropenia, thrombocytopenia, leukopenia.
- Cardiovascular system: lowering blood pressure, dizziness.
- Integumentary tissues: skin rash, dermatitis, eosinophilia, urticaria.
- Others: superinfection.